VThunter
a database for single-cell screening of virus target cells in animal kingdom
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Mouse

Scientific Name: Mus musculus

Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Euarchontoglires-> Glires-> Rodentia-> Myomorpha-> Muroidea-> Muridae-> Murinae-> Mus-> Mus

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Human coronavirus NL63

Family: Coronaviridae

Receptor: ACE2

Receptor ACE2 information

Summary: The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. [provided by RefSeq, Nov 2020] [NCBI]  [Proteinatlas]

Data Source

Data set information

Project Date Technology Tissue Condition Cell PMID/DOI
Vthunter_110001 2018.02 Microwell-seq Bladder Normal 2746 Link
Vthunter_110006 2018.02 Microwell-seq Brain Normal 3285 Link
Vthunter_110007 2018.02 Microwell-seq Brain Normal 753 Link
Vthunter_110008 2018.02 Microwell-seq EmbryonicMesenchymeE14.5 Normal 2771 Link
Vthunter_110010 2018.02 Microwell-seq Fetal FemaleGonad Normal 8462 Link
Vthunter_110011 2018.02 Microwell-seq Fetal Intestine Normal 6076 Link
Vthunter_110012 2018.02 Microwell-seq Fetal Lung Normal 6453 Link
Vthunter_110013 2018.02 Microwell-seq Fetal MaleGonad Normal 3472 Link
Vthunter_110014 2018.02 Microwell-seq Fetal Stomach Normal 6192 Link
Vthunter_110015 2018.02 Microwell-seq Kidney Normal 4682 Link
Vthunter_110016 2018.02 Microwell-seq Liver Normal 4424 Link
Vthunter_110017 2018.02 Microwell-seq Liver Normal 261 Link
Vthunter_110018 2018.02 Microwell-seq Lung Normal 2512 Link
Vthunter_110019 2018.02 Microwell-seq Lung Normal 1414 Link
Vthunter_110020 2018.02 Microwell-seq Lung Normal 3014 Link
Vthunter_110021 2018.02 Microwell-seq MammaryGland.Involution Normal 3510 Link
Vthunter_110022 2018.02 Microwell-seq MammaryGland.Involution Normal 1311 Link
Vthunter_110023 2018.02 Microwell-seq MammaryGland.Lactation Normal 6633 Link
Vthunter_110024 2018.02 Microwell-seq MammaryGland.Lactation Normal 6905 Link
Vthunter_110026 2018.02 Microwell-seq MammaryGland.Virgin Normal 2081 Link
Vthunter_110028 2018.02 Microwell-seq MammaryGland.Virgin Normal 648 Link
Vthunter_110035 2018.02 Microwell-seq NeonatalCalvaria Normal 3617 Link
Vthunter_110036 2018.02 Microwell-seq NeonatalHeart Normal 3948 Link
Vthunter_110038 2018.02 Microwell-seq NeonatalMuscle Normal 4044 Link
Vthunter_110039 2018.02 Microwell-seq NeonatalPancreas Normal 4571 Link
Vthunter_110041 2018.02 Microwell-seq NeonatalRib Normal 3082 Link
Vthunter_110043 2018.02 Microwell-seq NeonatalSkin Normal 3392 Link
Vthunter_110044 2018.02 Microwell-seq Ovary Normal 1931 Link
Vthunter_110045 2018.02 Microwell-seq Pancreas Normal 3610 Link
Vthunter_110046 2018.02 Microwell-seq PeripheralBlood Normal 3201 Link
Vthunter_110047 2018.02 Microwell-seq PlacentaE14.1 Normal 1873 Link
Vthunter_110048 2018.02 Microwell-seq PlacentaE14.2 Normal 2473 Link
Vthunter_110051 2018.02 Microwell-seq SmallIntestine Normal 3438 Link
Vthunter_110052 2018.02 Microwell-seq SmallIntestine Normal 1671 Link
Vthunter_110053 2018.02 Microwell-seq SmallIntestine Normal 1575 Link
Vthunter_110060 2018.02 Microwell-seq Uterus Normal 1704 Link
Vthunter_110066 2019.12 MARS-seq TotalBrain Normal 2304 Link
Vthunter_110101 2020.09 10X Genomics Teeth Teeth 2888 Link
Vthunter_110105 2018.07 10X Genomics Adipose Adipose 288 Link
Vthunter_110106 2016.02 10X Genomics PrimaryVisualCortex PrimaryVisualCortex 1787 Link
Featureplot of receptors

Featureplot of receptors

mRNA expression of ACE2 in human tissues   [NCBI]

Expression: Biased expression in small intestine (RPKM 93.7), duodenum (RPKM 69.0) and 5 other tissues

Protein expression of ACE2 in human tissues   [Proteinatlas]